Micky van de Ven Brace Ends The Toffees' Run at New Stadium
The Dutch defender emerged as the initial defender to score twice in a Premier League match for Tottenham since the Belgian defender in March 2013.
Match summary
Micky Van de Ven heads into the net twice in opening period
Everton's Jake O'Brien has equalizer ruled after video check
Senegalese midfielder scores final goal in 89th minute
The defeat is Everton's initial at their new ground
Micky van de Ven found the net on two occasions as Spurs extended their unbeaten run in away games in the top division and delivered the Toffees their initial loss at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their new ground at the dockside location, having left their historic home behind after more than a century at the conclusion of last season.
But Tottenham's leader Van de Ven pounced twice from corners in the opening 45 minutes to put their strong form at risk, and they were failed to mount a comeback before the midfielder - set up by former Toffees attacker the Brazilian - nodded in a third to seal the victory.
Jake O'Brien believed he had equalized the tally a short while after Van de Ven's opener, directing a bullet header past the Spurs keeper from an set-piece.
Beto, in the meantime, failed to convert a number of opportunities, while Vicario made a succession of fine stops to ensure the London club went five away games unbeaten in the English top flight.
But the VAR stepped in, advising the match official to review the score on the screen and the referee decided that the winger and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
The win moves the manager's side up to third in the division, five points off north London rivals and leaders the Gunners.
The Merseyside club stay in 14th position and are half a dozen points clear of the relegation zone.
Spurs breakdown: The defender fulfils duties at each end of the field
After a uninspiring weekday performance in the Champions League against Monaco, where they mustered a mere two shots on target, the manager opted for Randal Kolo Muani up front instead of ex-Everton forward Richarlison.
The new arrival was unable to make much of an impact before being replaced for the substitute after an hour on the pitch, but it emerged he proved unnecessary in the end.
Defender the Dutchman converted into an offensive threat to be feared.
Tottenham's opening strike came from a well-worked set-piece play, with Rodrigo Bentancur heading the ball back across the six-yard box for an unmarked Van de Ven to score.
And the captain - stepping up as skipper in the Argentine's absence - added his next goal in first-half stoppage time as he rose above Jordan Pickford to head home.
Van de Ven was equally impressive in defence, combining well with Kevin Danso as the duo handled superbly with the numerous deliveries thrown their way by Everton.
Everton analysis: Toffees lacking finishing touch
The club's new home had been a fortress, but it seems the freshness may have worn off slightly and supporters flocked to the exits after Sarr's third for Tottenham.
The end in Everton's winning streak at home won't be a major concern for the manager, but their striker situation are.
Beto and Thierno Barry - the Toffees' pair of recognised centre-forwards - had scored only one league goal combined before Sunday's outing.
And they were failed to add to that miserable tally on a wet and gloomy evening on in Liverpool.
Beto's form was epitomized when he opted to overhead kick a clear chance from near the goal, even with having space and opportunity to reposition for a more conventional shot that would have challenged Vicario.
Barry, as well, failed to influence the game after coming on for the starter in the 65th minute.
It was not for a shortage of opportunity. Most of Everton's offensive moves came through the winger and Ndiaye, who relentlessly delivered threatening crosses into the Tottenham box.
Upcoming fixtures for both teams?
The Toffees: The team head to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Tottenham: The London club go to Newcastle's ground on late October for their next round League Cup tie against Newcastle.